A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)

• Status: Completed
• Trial end date: 2009-07-21
• Target enrollment: 0
• Participant gender: Male

Summary

This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• Subject is an Asian Indian male between 18 to 45 years of age

• Subject is in good health

• Subject is a nonsmoker or has not used nicotine-containing products for six months

• Subject is willing to avoid strenuous activity

Exclusion Criteria:

• Subject has a history of stroke, seizures, or major neurological disorders

• Subject has irritable bowel disease or recurrent nausea, vomiting, diarrhea, or abdominal pain

• Subject has a history of high blood pressure requiring treatment

• Subject has history of cancer

• Subject has a history of diabetes