Overview

A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

Status:
Recruiting
Trial end date:
2027-09-30
Target enrollment:
Participant gender:
Summary
A Phase 3 multi-institutional study for treatment of children with newly diagnosed hepatoblastoma using a modified Paediatric Hepatic International Tumour Trial (PHITT) strategy incorporating a randomized assessment of sodium thiosulfate as auditory protection for children with localized disease, and response adapted therapy for patients with metastatic disease
Phase:
Phase 3
Details
Lead Sponsor:
Shanghai Children's Medical Center
Collaborators:
Children's Hospital of Fudan University
Shanghai Children's Hospital
Treatments:
Carboplatin
Cisplatin
Doxorubicin
Fluorouracil
Irinotecan
Liposomal doxorubicin
Sodium thiosulfate
Vincristine