A Multicenter Trial Evaluating the Efficacy of Nedaplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

• Status: Unknown status
• Trial end date: 2017-12-01

Summary

This study is a multicenter trial.The primary objective is to estimate short-term efficacy and acute toxicities of nedaplatin to the combination of docetaxel in neoadjuvant chemotherapy followed by nedaplatin in concurrent chemoradiotherapy, compared to cisplatin to the combination of docetaxel in neoadjuvant chemotherapy followed by cisplatin in concurrent chemoradiotherapy for patients with locoregionally advanced nasopharyngeal carcinoma.

Secondary objectives are to evaluate the overall survival, the distant metastases free survival, and disease free survival of patients with locoregionally advanced nasopharyngeal carcinoma treated with these regimens.Furthermore,analyze the cost-effectiveness of the regimens.

• Phase: Phase 3

Details

• Lead Sponsor: Guangxi Medical University
• Collaborators: 303rd Hospital of the People's Liberation Army; First People's Hospital of Yulin; Guangxi Naxishan Hospital; Guangxi Traditional Chinese Medical University; Guigang People's Hospital; Guilin Medical College; Liuzhou Cancer Hospital; Liuzhou Hospital of Traditional Chinese Medicine; LiuZhou People's Hospital; Liuzhou Railway hospital; Liuzhou Worker's Hospital; Liuzhou Workers Hospital; Nanning Second People's Hospital; People's Hospital of Guangxi; The Red Cross hospital of Wuzhou; The Red Cross hospital of YuLin; Wuzhou Red Cross Hospital
• Treatments: Cisplatin; Docetaxel; Nedaplatin