A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis
Status:
Terminated
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
This multi-center randomized controlled trial evaluates if the addition of intravenous
immunoglobulin to standard treatment of corticosteroids improves outcome in children and
adults with first episode of Transverse Myelitis of Neuro-myelitis optica. Half of
participants will receive corticosteroids alone, whilst the other half will receive
corticosteroids plus intravenous immunoglobulin.
Phase:
Phase 3
Details
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborators:
Alder Hey Children's NHS Foundation Trust Barts & The London NHS Trust Barts and the London School of Medicine and Dentistry Birmingham Children's Hospital NHS Foundation Trust Birmingham Women's and Children's NHS Foundation Trust Cardiff and Vale University Health Board Cardiff University Central Manchester University Hospitals NHS Foundation Trust Great Ormond Street Hospital for Children NHS Foundation Trust King's College Hospital NHS Trust King's College London Manchester University NHS Foundation Trust Newcastle-upon-Tyne Hospitals NHS Trust NHS Lothian North Bristol NHS Trust Nottingham University Hospitals NHS Trust Oxford University Hospitals NHS Trust Salford Royal NHS Foundation Trust University College, London University Hospital Birmingham NHS Foundation Trust University Hospital Southampton NHS Foundation Trust University Hospitals Bristol and Weston NHS Foundation Trust University Hospitals Bristol NHS Foundation Trust Walton Centre NHS Foundation Trust