A New Approach of Neostigmine in Unavoidable Post Operative Ileus

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baqiyatallah Medical Sciences University
• Treatments: Neostigmine

Criteria

Inclusion Criteria:

• Patients with acute colonic pseudo-obstruction who were 18 years of age or older

• Patients had to have a cecal diameter of at least 10 cm on plain radiographs

• Mechanical obstruction was ruled out by the finding of air throughout all colonic segments including the rectosigmoid on plain abdominal radiographs

Exclusion Criteria:

• Exclusion criteria included a base-line heart rate of less than 60 beats per minute or systolic blood pressure of less than 90 mm Hg; signs of bowel perforation

• With peritoneal signs on physical examination or free air on radiographs; active bronchospasm requiring medication

• Treatment with prokinetic drugs such as cisapride or metoclopramide in the 24 hours before evaluation

• A history of colon cancer or partial colonic resection

• Active gastrointestinal bleeding

• Pregnancy

• Positive history of Myocardial Infarction, Intestinal Resection or a serum creatinine concentration of more than 3 mg per deciliter (265 µmol per liter)