A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Hypotension occurs commonly during spinal anaesthesia for caesarean section with maternal and fetal adverse effects. The investigators developed a double-vasopressor automated system incorporating continuous non-invasive haemodynamic monitoring using NexfinTM with a two-step algorithm.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: KK Women's and Children's Hospital
• Treatments: Ephedrine; Oxymetazoline; Phenylephrine; Pseudoephedrine; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• age 21-45 years old,

• weight 40-90 kg,

• height 145-170 cm

Exclusion Criteria:

• contraindications to spinal anaesthesia,

• allergy to drugs used in the study, and

• those with uncontrolled medical conditions such as hypertension, diabetes mellitus, and cardiovascular disease