A Novel TBI Free Conditioning Protocol for Haploidentical Transplant in Acquired Aplastic Anemia:
Status:
Recruiting
Trial end date:
2021-06-30
Target enrollment:
Participant gender:
Summary
Severe and very severe aplastic anemia are life threatening disorders for which allogeneic
stem cell transplant is only curative treatment. However, matched sibling donor (MSD) is
available in only 25-35% cases. Pakistan has a population of around 203 million but there is
no donor registry available so there is no option available for matched unrelated donor (MUD)
transplants . Haploidentical transplant represents only curative option for patients lacking
MSD. Protocols involving post transplant cyclophosphamide require Total body irradiation
(TBI) and utilize peripheral blood stem cell(PBSC) as graft source. TBI is not available in
most of transplant centres across Pakistan due to lack of availability , cost and lack of
expertise. The investigators have conceived a novel TBI free conditioning regimen to be used
for haplo-identical Hemtopoeitic stem cell transplant in acquired aplastic anemia patients
Phase:
Phase 2
Details
Lead Sponsor:
Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan National Institute of Blood and Marrow Transplant (NIBMT), Pakistan