A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts
Status:
Withdrawn
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
This study represents a randomized, double blind placebo-controlled trial. Thirty cocaine
dependant patients will be included in this study during their hospitalization for
withdrawal. After the inclusion visit, they will be randomized to receive disulfiram 250
mg/day or placebo over the 15 days of their hospitalization. Main outcome criteria will be
evaluated during two TEP imaging sessions with 11Craclopride, before and after stimulation by
methylphenidate, 8 to 15 days after randomization.