A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
This research study is testing whether the local anesthetic lidocaine is as effective as
ropivacaine for post-operative pain control in continuous thoracic paravertebral nerve
blocks. Ropivacaine and Lidocaine are FDA-approved drugs that has been successfully used in
this hospital for post-operative pain control for the past few years, thus has become the
standard drugs used for this nerve block. Lidocaine has numerous potential advantages over
ropivacaine, such as faster onset of action, better safety profile and greater
anti-inflammatory action. Catheters placed near both sides of a patient's spine for
postoperative pain control are called thoracic paravertebral nerve blocks and are a part of
routine care. Through those catheters, a "numbing" medication, or local anesthetic, to block
the transmission of pain from the surgical incision to the spinal cord, thus reducing pain.
The research part of the study is whether subjects will receive either the local anesthetic
lidocaine or ropivacaine. The goal of this study is to determine whether the lidocaine
controls pain better and facilitates a faster recovery after abdominal surgery than
ropivacaine.
In this research study, the investigators will compare patient-reported pain scores, any
additional pain medication requirements for adequate pain control, time it takes for bowel
function to return to normal following surgery, as well as the incidence of any side effects,
such as numbness and weakness, subjects may experience between those receiving lidocaine
versus those receiving ropivacaine. The investigators will screen 100 patients and enroll 60
subjects into this study.