A Pharmacokinetic Study of Actinomycin-D and Vincristine in Children With Cancer

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To obtain a preliminary characterization of the plasma PK and metabolites of actinomycin-D in children with cancer.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Dactinomycin; Vincristine

Criteria

Inclusion Criteria:

• 6 months - 18 years

• Due to receive actinomycin-D as a component of cancer treatment

• Central venous catheter (e.g. Port-a Cath, Broviac)

• Informed consent of parent or legal guardian and patient assent when appropriate

Exclusion Criteria:

• Serious illness other than the primary diagnosis of cancer

• Weight < 5 kilograms

• Previous participation in CHP-810