A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia
Status:
Completed
Trial end date:
2003-11-01
Target enrollment:
Participant gender:
Summary
The pharmacokinetic behavior of vincristine in pediatric patients has not been well
characterized. The present study will obtain detailed information on vincristine
pharmacokinetics in patients being treated for standard risk ALL on CCG protocols 1952/1962.
A limited sampling strategy will be developed, and the interpatient and intrapatient
variability of vincristine pharmacokinetics in children will be studied. A correlation
between vincristine neurotoxicity and vincristine pharmacokinetics will be sought.