Overview
A Phase 1 Study to Evaluate EMP22 PD and EMP16 PK Versus Xenical® in Healthy Volunteers
Status:
Recruiting
Recruiting
Trial end date:
2024-12-01
2024-12-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This Phase I, active-controlled, randomised trial will be conducted in 2 parts. Part I aims to confirm the PD equivalence of EMP22 and Xenical® based on percent fecal fat excretion at steady state. EMP22 (also referred to as MR orlistat) has the same MR properties as EMP16 but lacks the acarbose component. Part II will explore the PK properties of EMP16 alone and vs. Xenical®. Part I will be conducted in a single-blind, cross-over fashion while Part II will have an open-label, fixed-sequence design. Healthy volunteers will be recruited to the trial.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Empros Pharma ABCollaborator:
CTC Clinical Trial Consultants ABTreatments:
Orlistat
Criteria
Inclusion Criteria:1. Willing and able to give written informed consent for participation in the trial.
2. Healthy male or female aged 20 to 55 years inclusive.
3. Participants with a BMI between 20 and 27 kg/m² or participants with a BMI >27 kg/m2
and normal body fat composition (10 to 25% for men and 20 to 30% for women measured
using a bioimpedance scale) at screening.
4. Weight stable (<5% self-reported change during the previous 3 months preceding
screening).
5. Participants with a self-perceived normality in defecation habits, normally with a
stool frequency of at least once daily.
6. Medically healthy participant without abnormal clinically significant medical history,
physical findings, vital signs, electrocardiogram (ECG) and laboratory values at the
time of the screening visit, as judged by the Investigator.
Exclusion Criteria:
1. History of any clinically significant disease or disorder which, in the opinion of the
Investigator, may either put the participant at risk because of participation in the
trial, or influence the results or the participant's ability to participate in the
trial including but not limited to:
- GI problems/diseases, e.g. inflammatory bowel diseases and irritable bowel
syndrome (IBS).
- Cholestasis.
- Previous GI surgery that might influence GI function significantly, such as
previous bariatric surgery, and previous gallbladder surgery as judged by the
investigator.
- Vitamin B12 deficiency or other signs of achlorhydria.
- Chronical malabsorption syndrome.
- History of severe allergic, cardiac or hepatic disease.
2. Any clinically significant illness, medical/surgical procedure or trauma within 4
weeks of the first administration of IMP.
3. Malignancy within the past 5 years, with the exception of in situ removal of basal
cell carcinoma.
4. Any planned major surgery within the duration of the trial.
5. Participants who are pregnant, currently breastfeeding, or intend to become pregnant
during the course of the trial.
6. Any positive result at the screening visit for serum hepatitis B surface antigen,
hepatitis C antibodies and/or human immunodeficiency virus (HIV).
7. Prolonged QTcF (>450 ms), cardiac arrhythmias or any clinically significant
abnormalities in the resting ECG at the screening visit, as judged by the
Investigator.
8. History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as
judged by the Investigator, or history of hypersensitivity to drugs with a similar
chemical structure or class as orlistat or acarbose.
9. Regular use of any prescribed or non-prescribed medications (including, but not
limited to, antacids, analgesics, herbal remedies, vitamins and minerals) within 2
weeks prior to the first administration of IMP except as outlined in Section 9.6.2.3.
10. Administration of another new chemical entity (defined as a compound which has not
been approved for marketing) or has participated in any other clinical trial that
included drug treatment within 3 months of the first administration of IMP in this
trial. Subjects consented and screened but not dosed in previous studies are not
excluded.
11. Current smokers or users of nicotine products. Irregular use of nicotine (e.g.,
smoking, snuffing, chewing tobacco) less than 3 times/week is allowed before the
screening visit.
12. Positive screening result for drugs of abuse or alcohol at the screening visit.
13. History of alcohol abuse or excessive intake of alcohol, as judged by the
Investigator.
14. Presence or history of drug abuse, as judged by the Investigator.
15. History of, or current use of anabolic steroids, as judged by the Investigator.
16. Excessive caffeine consumption defined by a daily intake of > 5 cups (1 cup =
approximately 240 mL) of caffeine containing beverages, as judged by the Investigator.
17. Plasma donation within 1 month of screening or blood donation (or corresponding blood
loss) during the last 3 months prior to screening.
18. The Investigator considers the participant unlikely to comply with trial procedures,
restrictions and requirements.