A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML
Status:
Completed
Trial end date:
2014-07-28
Target enrollment:
Participant gender:
Summary
This is a Phase I study with a conditional cohort expansion phase to evaluate the feasibility
of, and to obtain preliminary efficacy data about, pretreatment with Azacytidine (AZA) for 5
days followed by fludarabine/cytarabine chemotherapy regimen in pediatric acute myeloid
leukemia (AML) and acute lymphoblastic leukemia (ALL) patients who are refractory to primary
treatment or who relapsed.
Phase:
Phase 1
Details
Lead Sponsor:
Therapeutic Advances in Childhood Leukemia Consortium
Collaborators:
Gateway for Cancer Research University of Southern California