A Phase I Study of BMS-275183 (Oral Taxane) Given on a Daily Schedule in Combination With Esomeprazole (Nexium) in Patients With Advanced Cancer

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine what effects Esomeprazole (Nexium) has on increasing or decreasing the amount of oral taxane in the blood, and to determine the safety of oral taxane and effect of oral taxane on the cancer.

• Phase: Phase 1

Details

• Lead Sponsor: Bristol-Myers Squibb
• Treatments: Esomeprazole; Taxane

Criteria

Inclusion Criteria:

• Advanced cancers excluding cancers within the blood

• Adequate kidney and liver function

• > = 4 weeks from last course of chemotherapy

Exclusion Criteria:

• Inability to swallow capsules

• Other active medical disorder

• Abnormal heart function or use of drugs that affect the heart