A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To study the safety and pharmacokinetics (blood levels) of recombinant human CD4 immunoglobulin (rCd4-IgG) in patients with AIDS or AIDS related complex (ARC) who have failed or declined therapy with zidovudine (AZT). An additional goal of the study is to obtain a preliminary indication of the antiviral effects of Cd4-IgG in patients with AIDS or ARC.

Other approaches in addition to existing treatment of HIV infection need to be evaluated. One approach may be to block HIV infection by interrupting the assembly of the virus within the cell or the budding of virus from the membrane of the infected cell. In addition, blocking the attachment of HIV to its cellular receptor may offer another point of attack. HIV binds to the CD4 receptor on the target T4 lymphocyte and the envelope glycoprotein of the virus (gp120) is capable of high affinity binding to CD4. Any agent that prevents the attachment of gp120 to the CD4 receptor should be able to block virus transmission and spread. Recently, scientists have succeeded in producing highly purified recombinant soluble human CD4. Recombinant CD4 is capable of binding to HIV envelope protein (gp120) and inhibiting HIV infectivity in test tube studies. Potential therapeutic benefit in patients with HIV infection could be derived from either or both of these biologic effects. In order to extend the length of time that rCD4 stays in the body, the compound has been modified by combining it with a human immunoglobulin of the IgG1 class (IgG).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Collaborator: Genentech, Inc.
• Treatments: Antibodies; CD4 Immunoadhesins; Immunoglobulins

Criteria

Inclusion Criteria

Patients must fulfill the following criteria:

• Diagnosis of AIDS or AIDS-related complex, according to CDC criteria, in previously documented HIV seropositive individuals.

• Failure to tolerate or respond to zidovudine (AZT) therapy for HIV infection or a decision to decline such therapy.

• Willingness to abstain from all other experimental therapy for HIV infection during study period.

• Life expectancy of at least 3 months.

• Patients must be able to sign a written informed consent form.

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Serious active opportunistic infection or malignancies not specifically allowed.

Concurrent Medication:

Excluded:

• Oral or intravenous acyclovir for herpes.

• Zidovudine (AZT).

• Interferon.

• Corticosteroids.

• Nonsteroidal anti-inflammatory agents (NSAIDS).

• Intravenous acyclovir.

• Other known immunomodulatory agents.

• Other experimental therapy.

Patients with the following are excluded:

• Serious active opportunistic infection or malignancies not specifically allowed.

Prior Medication:

Excluded within 4 weeks of study entry:

• Zidovudine (AZT).

• Chemotherapy.

• Immunomodulatory agents.

• Other experimental therapy.