A Phase I Study to Assess Novel Cream in a Psoriasis Plaque Test

• Status: Completed
• Trial end date: 2008-03-07
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate dose-response relationship, antipsoriatic efficacy and safety of different concentrations of topical formulations with AN2728 in subjects with psoriasis vulgaris.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pfizer
• Treatments: Betamethasone; Betamethasone benzoate; Betamethasone sodium phosphate; Betamethasone Valerate; Betamethasone-17,21-dipropionate

Criteria

Inclusion Criteria:

• male subjects aged 18 years or older

• subjects with psoriasis vulgaris in a chronic stable phase and stable plaques with an area sufficient for five treatment fields

• the physical examination must be without disease findings unless the investigator considers an abnormality to be irrelevant to the outcome of the study

• written informed consent obtained

Exclusion Criteria:

• subjects with psoriasis guttata or pustular psoriasis

• subjects who require systemically acting medications for the treatment of psoriasis, which might counter or influence the study objectives, e.g. corticosteroids, cytostatics

• local treatment with antipsoriatics (like vitamin D, dithranol, glucocorticosteroids; except for salicyclic acid in vaseline) in the 4 weeks preceding and during the study; and any antipsoriatic treatment on the plaques (including corticosteroids, except for salicyclic acid) in the 8 weeks preceding and during the study.

• systemic treatment with antipsoriatics in the three months preceding and during the study

• treatment with systemic or locally acting medications which might counter or influence the study aim (e.g. MAO inhibitors, anti-epileptic drugs, anti-psychotic drugs) or medications which are known to provoke or aggravate psoriasis, e.g. Beta-blocker, antimalarial drugs and lithium drugs within two weeks before the beginning of the study and during the study.

• known allergic reactions to the active ingredients or other components of the study preparations or comparators

• blood pressure and heart rate outside the following allowed ranges: systolic blood pressure 80-160 mm Hg, diastolic blood pressure 60 - 100 mm Hg, heart rate 40-120 beats/min

• evidence of drug abuse

• UV-therapy within 4 weeks before beginning and during the study

• Symptoms of a clinically significant illness that may influenced the outcome of the study in the 4 weeks before and during the study

• participation in another clinical trial involving pharmaceutical products in the 4 weeks preceding and during the study

• in the opinion of the investigator or physician performing the initial examination the patient should not participate in the study, e.g. due to probable noncompliance or inability to understand the study and give adequately informed consent

• subject is institutionalized because of legal or regulatory order