A Phase II Clinical Trial of Hydronidone Capsules(F351) in Patients With Liver Fibrosis Induced by HBV Chronic Hepatitis

• Status: Unknown status
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To explore the effective dose and safety of the effect of hydronidone and entecavir on hepatic fibrosis in chronic viral hepatitis B.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Genomics, Inc.
• Treatments: Entecavir

Criteria

Inclusion Criteria:

1. Aged 18-65, all genders.

2. History of chronic hepatitis B, HBsAg positive≧six months.

3. ALT4. Significant liver fibrosis confirmed by liver biopsy.

5. HBeAg positive patients, HBV DNA>2.0×104 IU/mL (copies/mL); HBeAg negative patients，HBV DNA>2.0×103 IU/mL (104copies/mL).

6. Having not accepted the antiviral therapy with interferon and/or nucleoside analog.

7. Having not taken anti-inflammatory drugs to protect liver within 1 month before selection.

8. Capable of understanding and signing the informed consent before the study.

Exclusion Criteria:

1. Failing to meet any one requirement of the inclusion criteria.

2. Having suffered massive hemorrhage of gastrointestinal tract within 3 months before selection

3. TBiL>three-fold ULN.

4. AFP>50 ug/L

5. PLT≦60000ug/L

6. Having obvious space-occupying lesion in liver as shown by B ultrasound examination.

7. With a portal vein ≧1.2cm wide as shown by B ultrasound examination.

8. BMI index>30.

9. The patient who suffered from liver function decompensation hepatic cirrhosis and liver neoplasms.

10. The patient with alcoholic, drug-induced, hereditary, immune and other viral and non- viral chronic hepatitis.

11. The patient with angiocarpy, lung, kidney, incretion, nerve and blood system disease and mental disease.

12. The patient with active peptic ulcer.

13. Gestational and breast feeding women.

14. The subject is the legal disabled person according to the Law of the People's Republic of China on the Protection of Disabled Persons of the April 2008 edition.

15. The subject who participated in other drug tests within recent 3 months.

16. The patient who is suspected with poor compliance or disagrees to participate in the test.

17. The patient who is considered by other investigators not to be suitable for participating in the study.