A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms
Status:
Completed
Trial end date:
2021-03-31
Target enrollment:
Participant gender:
Summary
- This is an open label single-arm, single-institution stud to evaluate the efficacy and
safety of SGI-110 in Philadelphia chromosome negative (Ph-) Myeloproliferative Neoplasms
(MPN) (excluding PV, ET and primary/secondary myelofibrosis). The study will enroll
approximately 50 patients at the Weill Cornell Medical College.
- Enrollment onto this clinical study is expected to be completed in approximately 36
months. The total study duration will depend on individual response, evidence of disease
progression and tolerance. Participants will be followed monthly for six months after
removal from study or until death, whichever occurs first.
Key eligibility:
- Confirmed diagnosis of Ph- MPN and had
- No chemotherapy or radiation treatment within 2 weeks prior to study entry.
- Subjects meet other protocol-defined criteria related to baseline screening procedures.