A Phase Ib Study to Assess Safety and Efficacy of Oral Icaritin in Advanced Solid Tumors

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

to assess the safety, tolerability，PK and efficacy profile of two doses (600mg,800mg,BID) of Icaritin in advanced solid tumor patients in China

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Academy of Medical Sciences
• Collaborator: Beijing Shenogen Biomedical Co., Ltd

Criteria

Inclusion criteria:

1. age≥18 years old and ≤65

2. The patients with advanced breast tumors，hepatocellular carcinoma (HCC) or other advanced solid tumor patients who are confirmed through histologic or cytologic diagnosis to be ER positive or subjects whom investigators believe may benefit from the trial.

3. Patients with advanced cancer that relapsed after or failed previous standard treatment

4. 19≤BMI index≤30

5. No serious heart, liver,lung and kidney diseases.

6. .Received at least one anti-cancer treatment (including chemotherapy, radiotherapy, biological or endocrine treatment). And the last treatment must be at least four weeks before study enrollment or after 5 times of the drug's half-life time has passed. The surgery treatment must be more than three months.

7. Life expectancy of at least 12 weeks. 8 .Patients who can cooperate to observe AE and efficacy.

9. No any other concurrent anti-cancer treatment 10. A signed informed consent must be obtained prior to performing any study specific procedures.

11. The Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 12. Female:Women with childbearing potential must have a negative pregnancy test performed 13. HCC patients: Child-Pugh Class of A or B

Exclusion Criteria:

1. Have a known hypersensitivity to flavonoid drugs.

2. Hepatic:

1. HCC patients : ALB <2.8g/dL, TB>3.0mg/dL, ALT and AST > 2.5 times the upper limit of Normal

2. Advanced breast tumors or other advanced solid tumor patients: ALB >limit of normal, TB> the upper limit of normal, ALT and AST > upper limit of Normal Renal: Serum Creatinine >1.5 times the upper limit of normal. Blood test: Absolute neutrophil count (ANC) < 1.5 × 109/L, Platelet count < 90 × 109/L, Hemoglobin <9 g/dL.

3. PT/APTT >1.25 times the upper limit of normal. HCC patients: PT > 5 seconds above control

4. Suffered from thrombotic disease.

5. Serum Ca > the upper limit of normal.

6. Not recovered from toxic effects of previous anti-cancer treatments or surgery.

7. Any serious or uncontrollable concomitant systemic disorder (such as unstable respiratory disorders, cardiovascular, hepatic or kidney disorders.) or active infection which will influence the clinical trial.

8. CNS metastases or invade requiring treatment for unstable status or various psychiatric disorders

9. Malabsorption or other disease which will affect the drug absorption,distribution,metabolism and excretion.

10. Other concurrent malignancies with the exception of cervical cancer in situ or squamous cell carcinoma of the skin .