A Physiological Study on Downregulation of EGF-receptors in the Skin by Topical Exposition With EGF

• Status: Unknown status
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Investigation of EGF-Receptor Downregulation by topical EGF (dermal cream) exposition.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ennar Pharmaceuticals AF
• Collaborator: University of Zurich
• Treatments: Mitogens

Criteria

Inclusion Criteria:

• Informed consent

• Mild to moderate psoriasis (all types) with active plaques on both body sides accessible for biopsy and self product application

• EGFR immunohistochemistry score > 5

• Male

• Age 18-60 years

Exclusion Criteria:

• Systemic psoriasis treatment 3 months prior and during the study

• Local psoriasis treatment on the investigational sites in the last 30 days or during the study

• Known hypersensitivity or allergy to the EGF containing product (Newskin) and/or to Vaseline/10% salicylic acid and/or to local anaesthetics of the amid type

• Known or suspected non-compliance to study protocol Coagulopathy or treatment with anticoagulants

• History of malignant disease Other clinically relevant concomitant disease state Participation in another investigational drug study in the last 30 days