A Pilot Comparison Study of Vibrating Mesh Versus Standard Jet Nebuliser for Bronchodilator Delivery in COPD

• Status: Completed
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment of chronic obstructive pulmonary disease (COPD) incorporates various modes of inhalation therapy. The response to treatments is dose dependent thus applying the most efficient device to administer the treatment is integral. Evaluation of the efficacy of nebulisation devices in the treatment of COPD is limited. Technological development in recent years has led to new devices that optimize lung deposition and reduce the time needed for treatment.

The aim of this study is to compare the vibrating mesh and jet nebuliser methods of delivering bronchodilator medication to patients hospitalised with an acute exacerbation of COPD, with respect to lung function and efficacy in spontaneously breathing patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beaumont Hospital
• Collaborator: Aerogen
• Treatments: Albuterol; Bronchodilator Agents; Ipratropium

Criteria

Inclusion Criteria:

• Hospital Inpatients admitted with an acute exacerbation of COPD

• Age >40

• COPD Stage 2-4 moderate to severe (FEV1/FVC <0.70;FEV1<80%)

• History of physician-diagnosed COPD

• COPD exacerbation between day 2 and day 7 of admission

Exclusion Criteria:

• Confusion

• Significant hypoxia/unstable medical condition

• Allergy or contraindication to salbutamol and/or ipratropium

• Pneumonia

• Pregnancy