A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

Pilot study to compare the efficacy and safety of 3-day, twice-daily regimens of nitrofurantoin and ciprofloxacin in emergency department (ED) patients presenting with UBC.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Iowa
• Treatments: Ciprofloxacin; Nitrofurantoin

Criteria

Inclusion Criteria:

• pre-menopausal females

• ages 18-45 years old

• symptoms of a UTI (dysuria, frequency, urgency)

Exclusion Criteria:

• Onset of symptoms >7 days prior to the ED visit

• Non-English speaking

• Symptoms of pyelonephritis

• Diabetic

• Indications of sepsis

• Immunocompromised

• Currently using prophylactic antimicrobials

• Medications that could interfere with study drug

• Pregnant

• Lactating

• History of kidney or liver disease

• Vaginal symptoms

• Presence of a urinary catheter

• Treatment for UBC <2 weeks prior to ED visit

• Known allergy to study drug

• Unavailable for follow-up