A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
Status:
Recruiting
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine
complication of chronic kidney disease that has been associated with impaired quality of life
and cardiovascular complications. While levothyroxine is one of the most frequently
prescribed medications in chronic kidney disease patients, little is known about its efficacy
and safety in this population. This study will investigate 1) whether levothyroxine
adequately lowers thyrotropin (TSH) levels to therapeutic target ranges, and 2) if thyroid
hormone replacement improves quality of life and cardiovascular markers, without leading to
wasting in dialysis patients.
Phase:
N/A
Details
Lead Sponsor:
University of California, Irvine
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)