A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics
Status:
Terminated
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
This study focuses on severe asthmatics and their asthma symptoms. 40% of asthma patients
continue to experience symptoms and up to 5% of these have difficult-to-control asthma
despite continually improving treatments. Severe asthmatics experience clinically-significant
worse health-related quality of life than those than those with less severe asthma. Poorer
health-related quality of life can be as a consequence of frequent, severe symptoms, which
prevent the patient from continuing a normal, active lifestyle. The Royal Brompton Hospital
uses the treatment regimen of intravenous (IV) Aminophylline and IV Hydrocortisone which
appears to improve symptoms and reduce exacerbations. At present there is anecdotal evidence
to support these assumptions. The objective of this study is to determine whether there is
any objective evidence of improvement, in particular looking at lung function, symptoms and
cardiovascular function.