A Pilot Study for Optimizing Meropenem Administration in the ICU

• Status: Recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Can antibiotic drugs be administered faster and make acceptable serum concentrations if we give short but multiple infusions compared to long and fewer infusions? In this study we will compare giving meropenem 1 gram 6 times daily in 15 minutes infusions to the recommended 2 gram 3 times daily in 3 hours infusions. In patients in the intensive care unit, the need for intravenous access is of essence. If 6 short infusions results in the same serum concentrations as 3 long infusions, we will increase intravenous access from 15 to 22.5 hours daily.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oslo University Hospital
• Treatments: Meropenem

Criteria

Inclusion Criteria: Inclusion criteria are patients ≥ 18 years admitted to the ICU at Oslo University Hospital, Rikshospitalet, who shall be treated with meropenem because of proven or suspected serious infection, who give their written informed consent either directly or through next of kin.

Exclusion Criteria: Exclusion criteria are 1) known hypersensistivity to betalactam antibiotics, 2) the use of valproat, 3) pregnancy and 4) the lack of consent.