A Pilot Study for Pharmacokinetic Parameter of Colchicine in Patient Taking Rifampin

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the colchicine concentration before and after the administration of rifampicin.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Colchicine; Rifampin

Criteria

Inclusion Criteria:

• from 18yrs to 80yrs , man and women

• the patient who are taking rifampicine over 2weeks

• the patient sign on the concent form

Exclusion Criteria:

• the patient have experience to take medication that have an effect on renal function

• the patient have hypersensitivity to colchicine

• At least, the average level of two separate blood pressure ( 2min interval ) shows that SBP <= 100 mmHg or >=160 mmHg and DBP <=60 mmHg >=100 mmHg, or Heart rate < 40 beats/min or > 90 beats/min

• uncontrolled hypertension

• serum albumin < 3.5, > 5 g/dL

• acute hepatitis or the level of AST or ALT is over 2times of normal range or the level of bilirubin is over 2.0 mg/dL

• the patient who have gastro-intestinal disease ( ex, crohn's disease, acute or chronic pancreatitis, ulcer )or who have the surgical history of gastrointestine.

• the patient who should take azathioprine, mercaptopurine, cyclophosphamide, Losartan, benzbromarone,fenofibrate,furosemide ,probenecid

• the patient who had taken part in the other study within 3months

• the patient who had gotten blood transfusion

• pregnant, breast feeding