A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study will be to assess the frequency of return of spontaneous circulation (ROSC), survival to admission, survival to discharge from the hospital, and neurologic function at time of discharge from the hospital among patients experiencing out of hospital cardiac arrest randomized to receive either intra-arrest induction of therapeutic hypothermia (IATH) or post-arrest therapeutic hypothermia (TH).

Specific aims

1. Develop and test methodologies for randomizing out-of-hospital cardiac arrest (OOHCA) patients to receive one of two therapeutic hypothermia treatments in the prehospital environment.

2. Randomize patients experiencing OOHCA to receive either IATH or post-arrest TH and assess the frequency of ROSC, survival to admission, survival to discharge, and neurologic function.

3. Estimate the most efficacious volume of chilled saline administered during the intra arrest period.

4. Identify barriers and strategies for the successful implementation of this project as a multicenter randomized trial.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Carolinas Medical Center

Criteria

Inclusion Criteria:

• Cardiac arrest of presumed medical etiology in the out-of-hospital setting

Exclusion Criteria:

• Traumatic Cardiac Arrests

• Cardiac Arrests Due to hemorrhage

• Cardiac arrests involving children or young adults

• Patients presumed to be pregnant

• Patients with a do not resuscitate