A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The objective of this study will be to assess the frequency of return of spontaneous
circulation (ROSC), survival to admission, survival to discharge from the hospital, and
neurologic function at time of discharge from the hospital among patients experiencing out of
hospital cardiac arrest randomized to receive either intra-arrest induction of therapeutic
hypothermia (IATH) or post-arrest therapeutic hypothermia (TH).
Specific aims
1. Develop and test methodologies for randomizing out-of-hospital cardiac arrest (OOHCA)
patients to receive one of two therapeutic hypothermia treatments in the prehospital
environment.
2. Randomize patients experiencing OOHCA to receive either IATH or post-arrest TH and
assess the frequency of ROSC, survival to admission, survival to discharge, and
neurologic function.
3. Estimate the most efficacious volume of chilled saline administered during the intra
arrest period.
4. Identify barriers and strategies for the successful implementation of this project as a
multicenter randomized trial.