A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease
Status:
Completed
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
Part 1: A pilot study in patients with homozygous S (HbSS) or hemoglobin S with beta zero
thalassemia(HbS-βo thalassemia), with the aim of examining the effect of intravenous NAC
treatment on plasma VWF parameters and measures of redox and RBC function.
Part 2: A pilot study in patients with sickle cell disease admitted to the hospital in
vaso-occlusive crisis to determine the effects of NAC infusions on plasma VWF parameters and
measures of redox and RBC function, and on measures of pain and hospital length of stay.