A Pilot Study on the Use of Prophylactic Antibiotics for EUS-guided Pancreatic Cyst Aspiration

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Our hypothesis is that a single dose of antibiotics at time of EUS-guided pancreatic cyst aspiration is equally effective to the usual regimen of 3 days of post-procedural antibiotics.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kaiser Permanente
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ciprofloxacin

Criteria

Inclusion Criteria:

• Patients between the age of 18-90 who present for an EUS / pancreas cyst evaluation

Exclusion Criteria:

• Patients outside the age range

• Patient-related factors (unable to provide consent, unable to understand English, allergic to cipro)

• High-risk patients for infective endocarditis

• Bacterial infection or use of antibiotics within 6 weeks of EUS

• Pancreatitis within the past 6 months

• Underlying immunosuppression (for example, uncontrolled diabetes - such as hemoglobin A1c above 7 or glucose > 180; renal failure; cirrhosis; pre-existing malignancy especially hematologic malignancy such as leukemia / lymphoma / multiple myeloma; HIV/AIDS)

• Currently taking immunosuppressive medications (for conditions such as rheumatoid arthritis, inflammatory bowel disease, organ transplant)

• Radiographic or endosonographic evidence of cyst cavity debris / necrotic debris

• Severe systemic disease (for example, NYHA class III or IV heart failure, oxygen-dependent COPD)