A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes. The traditional use of narcotics is challenging as the therapeutic window between analgesia and suppression of breathing becomes narrow with the intense pain and high doses of narcotics needed for dressing changes.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Manitoba
• Treatments: Nitrous Oxide

Criteria

Inclusion criteria

• adult burn patients admitted to the Health Sciences Centre

• total body surface area burned of 5-20%

Exclusion criteria

• admitted to intensive care unit

• unable to participate in the measurement outcomes (sedated, cognitively impaired, unable to understand English or visually impaired)

• medical condition that precludes using nitrous oxide (respiratory disease and significant cardiovascular disease 5).

• pregnant

• physically unable to hold the canister

• <90% SaO2 on room air

• face burn

• pre-injury narcotics (relative exclusion)

• use of IV ketamine

• pre-existing lung injury