A Pilot Trial of Itraconazole Pharmacokinetics in Patients With Metastatic Breast Cancer
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Cancer cells need to be able to make new blood vessels in order to keep growing. This is
called angiogenesis. In a laboratory setting, the drug itraconazole was shown to help stop
the growth of new blood vessels (anti-angiogenesis). It is hoped that itraconazole will
prevent new blood vessels from forming in humans too.
The purpose of this study is to look at how the body processes and breaks down itraconazole
(called pharmacokinetics). This study will also measure markers in your blood to see if
itraconazole stops new blood vessels from forming. The safety of itraconazole will also be
tested to see what effects (good and bad) it has on you and your breast cancer.