A Pre-surgical Study of LDE225 in Men With High-risk Localized Prostate Cancer
Status:
Completed
Trial end date:
2017-01-18
Target enrollment:
Participant gender:
Summary
This trial is designed as a randomized two-arm (LDE225 vs. observation groups) open-label
prospective clinical trial in men with localized high-risk prostate cancer undergoing radical
prostatectomy.
The investigators propose to determine the effects of LDE225 on neoplastic prostate tissue
from men at high risk of systemic disease progression, by comparing pre-surgical core-biopsy
specimens to tumor tissue harvested at the time of prostatectomy.
Phase:
Phase 1
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins