A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Antidepressants is the primary treatment for depression, but only less than 50% of the
patients get clinical remission. There is no objective markers to select antidepressants for
clinical treatment . Clinical choose usually use experience and waste a lot of time, even the
patients cannot be treated timely and effectively. The investigators found that the later
antidepressant effect for 8 weeks is related with early brain functional response. Present
prospectively drug treatment and follow-up study intends to adopt pharmacological imaging
research methods to detect the brain function or structure change of three different
mechanisms of antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs,
escitalopram), serotonin and norepinephrine reuptake inhibitors (SNRIs, duloxetine),
norepinephrine and dopamine reuptake inhibitors (NDRIs, bupropion) in depression patients.
Brain functional or structural magnetic resonance imaging data were collected at baseline, 1
days, 14 days and 12 weeks after treatment. The investigators want to observe the changes of
brain functional networks and structure at different time points, acute and chronic treatment
induced during drug treatment. Combined with the blood concentration detection, symptom
change, cognitive function tests, the investigators also hope to determine the different
mechanisms of drug efficacy of antidepressants with different mechanisms. The second aim is
to explore different mechanisms of brain function for effective or ineffective drug response.
The results of the study will help to further explain the mechanism of different
antidepressants, to facilitate the development of early indicators for drug efficacy and
individual treatment decision.