A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)

• Status: Withdrawn
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Diuretics; Furosemide; Metolazone; Spironolactone

Criteria

Inclusion Criteria:

1. dyspnea at rest or minimal activity

2. tachypnea (respiratory rate > 20/min) or rales or pulmonary edema on chest X-ray

Exclusion Criteria:

1. hospitalization for acute heart failure decompensation

2. cardiogenic shock (Systolic Blood Pressure < 80mmHg)

3. Need or plan for renal replacement therapy (dialysis, kidney transplant)

4. serum creatine level > 2.5mg/dl

5. serum potassium (K+) > 5.5mg/dl

6. Age > 80 years old or poor compliance patients

7. allergy, adverse drug reaction, hypersensitivity to any kinds of diuretics

8. life expectancy < 6 months (e.g. metastatic malignancy, liver cirrhosis)

9. pregnancy or women at age of childbearing potential