A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. The aim of this study is to investigate the alteration of complement C3 in patients with severe abdominal sepsis and evaluate the role of complement C3 depletion in prognosis of such patients. The relationship between complement C3 depletion and adaptive immunity is studied meanwhile.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jinling Hospital, China
• Treatments: Complement System Proteins; Norepinephrine

Criteria

Inclusion Criteria:

• Clinical diagnosis of severe abdominal sepsis

Exclusion Criteria:

• Age < 18 or > 60 years

• Pregnancy

• Leucopenia from radiochemical therapy due to malignant tumor

• Any primary diagnosis other than sepsis

• Confirmed immunodeficiency

• Requirement for blood transfusion, plasmapheresis, or immediate surgery