Overview

A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib

Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The aims of this study are: - To evaluate the benefits of the addition of bortezomib to standard rituximab with cyclophosphamide, doxorubicin, vincristine, prednisolone (R-CHOP) therapy in Diffuse Large B-cell Lymphoma (DLBCL). - To determine whether molecular phenotype effects the benefits derived from the addition of bortezomib.
Phase:
Phase 3
Details
Lead Sponsor:
University Hospital Southampton NHS Foundation Trust
Collaborator:
Janssen-Cilag Ltd.
Treatments:
Bortezomib
Cyclophosphamide
Doxorubicin
Liposomal doxorubicin
Methylprednisolone
Methylprednisolone Acetate
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Rituximab
Vincristine