A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
The main purposes of this study are to find out if the study drug losartan (Cozaar) or
placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to
insulin) and to measure the effect of the study drug losartan or placebo on how the arteries
in your arm dilate (enlarge to carry more blood).
We hope to learn if taking losartan changes the amount of certain proteins in the blood that
effect blood vessel function.
Losartan is approved by the US FDA to treat high blood pressure. It will take approximately 4
months for you to complete this study.