A Randomized Controlled Trial Comparing Urea Loaded Nanoparticles to Placebo: a New Concept for Cataract Management
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
Cataract is the leading cause of vision loss and blindness in the world,surgery is the only
available option to correct the problem and the major reasons for low cataract surgical rates
include low demand because of fear of surgery, high cost of surgery and poor visual results
but new research raises the hope that someday, cataracts could be cured with simple eye
drops. This is the first report for preparing urea-loaded NPs eye drops for cataract therapy.
Enhancement of the urea efficacy is accomplished by using polymeric NPs based on the
amphiphilic block copolymer Pluronic®F-127 (PF) which is a hydrophilic nontoxic copolymer
widely used as a pharmaceutical excipient for its stabilizing properties and capability to
increase the solubility.