Overview
A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands
Status:
Terminated
Terminated
Trial end date:
2010-08-01
2010-08-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
The purpose of this study is to assess the effectiveness of intermittent preventive treatment in pregnancy (IPTp) with Sulphadoxine-pyrimethamine compared to chloroquine prophylaxis in Honiara, Solomon Islands for prevention of malaria and it's adverse effects in pregnancy.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Ministry of Health and Medical Services, Solomon IslandsCollaborator:
World Health OrganizationTreatments:
Chloroquine
Chloroquine diphosphate
Fanasil, pyrimethamine drug combination
Pyrimethamine
Sulfadoxine
Criteria
Inclusion Criteria:- Pregnant women aged 15 to 49 years
- Attending ANC clinic for the first time in this pregnancy
- Assigned routine ANC at a HCC health clinic
- Has experienced quickening (feeling the movements of the fetus)
- Gestation of 16 weeks to 32 weeks (as assessed by the last menstrual period [LMP] or
by palpation if LMP is not available)
- Willing to adhere to all requirements of study
- Willing to provide informed written consent
- Planning to stay in Honiara for antenatal care and delivery
Exclusion Criteria:
- Used chloroquine prophylaxis in the current pregnancy before this ANC visit
- A history of allergic reaction to sulfa drugs (SP or cotrimoxazole
- Haemoglobin of < 7 g/dl
- Using folic acid in a dose of 5 mg daily (a dose of 1 mg daily or less is acceptable)
- Not willing to adhere to study requirements
- Women who are severely ill