A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand
Status:
Completed
Trial end date:
2005-08-01
Target enrollment:
Participant gender:
Summary
Herpes infection is an important co-factor in HIV transmission. A recent meta-analysis
demonstrated that HSV infection contributed to a 2-fold increased risk of HIV transmission.
Suppressive therapy with acyclovir has been a method proposed to reduce HIV transmission. We
are conducting a randomized controlled cross-over trial to evaluate the effect of acyclovir
suppressive therapy on HIV genital shedding in women co-infected with HIV-1 and Herpes
Simplex Virus Type-2 (HSV-2) in Thailand.