A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study if to evaluate the effectiveness of prophylactic antibiotics given during surgery in reducing the concentration of bacteria in a burn wound after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medstar Health Research Institute
• Treatments: Cefazolin; Clindamycin; Clindamycin palmitate; Clindamycin phosphate

Criteria

Inclusion Criteria:

1. Subject age ≥ 18 years old at the time of consent

2. Burn wound sustained less than 48 hours prior to the time of presentation to MedStar Washington Hospital Center

3. Burn wounds solely due to a thermal mechanism

4. Total body surface area burned ≤ 10%

5. Anticipated to require a single grafting procedure

6. Able to provide informed consent to participate

Exclusion Criteria:

1. Positive pregnancy test in females of child bearing age

2. Antibiotic administration within 30 days prior to admission

3. Known / documented beta lactam allergy and clindamycin allergy

4. Presence of burn wound cellulitis or infection pre-operatively

5. Intraoperative discovery of infection

6. Incarceration

7. Presence of factors that may affect wound healing, per clinician judgment, such as chronic malnutrition and immunocompromised state