A Randomized Double Blind Controlled Trial Comparing Sugammadex and Neostigmine After Thoracic Anesthesia
Status:
Terminated
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
At the end of anesthesia it's important to avoid residual neuromuscular block to ensure
adequate respiratory function preventing postoperative pulmonary complications. This trial
compares the neuromuscular block reversal with different drugs (sugammadex vs neostigmine)
after thoracic anesthesia. The trial main objective is to demonstrate that sugammadex is
faster than neostigmine to reach a Train-of-four-Ratio (TOF-ratio) of 0.9 after thoracic
anesthesia, demonstrating that sugammadex allows a faster extubation. Other main purpose is
to verify if there is a difference between sugammadex and neostigmine as regards adverse
events after extubation and in the postoperative period (until the 30th day after surgery).
Note: TOF-ratio is defined as the ratio of the fourth muscular twitch/first twitch value
during an accelerometric train-of-four stimulation.
Phase:
Phase 4
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano