A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Relationship Between Intraoperative Intravenous Acetaminophen and Postoperative Opioid Avoidance for Ambulatory Surgical Procedures

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a research study to determine if giving acetaminophen intravenously in hte operating room will decrease the number of patients who require additional pain medicine, such as morphine, after surgery in the recovery room.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Diego
• Collaborators: Cadence Pharmaceuticals; Mallinckrodt
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Undergoing ambulatory surgery under general anesthesia

• Expected postoperative pain to be mild-moderate

• Age 18 years or older

• Have an ASA physical status or 1, 2, or 3

Exclusion Criteria:

• Anticipated peripheral or neuraxial nerve block

• Any physical, mental or medical conditions which may confound quantifying postoperative pain resulting from surgery

• Current chronic opioid or tramadol use

• History of alcohol or opioid abuse

• Known allergy to the study medications

• Pregnancy

• Any health condition requiring greater than 100 micrograms of fentanyl during anesthesia induction

• Treated with any acetaminophen-containing medication in the previous 8 hours

• Treated with MAO inhibitors within 10 days prior to surgery

• Inability to communicate with the investigators and hospital staff

• Known or impaired liver function