A Randomized Trial of Three Regimens to Prevent Tuberculosis in HIV-Infected Patients With Anergy
Status:
Completed
Trial end date:
1998-12-01
Target enrollment:
Participant gender:
Summary
INTRODUCTION. To evaluate the efficacy of three regimens of prophylactic therapy for
tuberculosis in HIV-infected patients with anergy. METHODS. Prospective, multi-center,
randomized, comparative, and open clinical trial. Anergy was defined as absence of induration
in response to three antigens (PPD, Candida albicans and parotiditis antigen) applied by the
Mantoux method. Patients were randomized into one of the following prophylactic treatment
groups: isoniazid for six months (6H), rifampin plus isoniazid for three months (3RH),
rifampin plus pyrazinamide for two months (2RZ) or no treatment (NT). After completion of
treatment, patients were followed up for two years.