A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
This exploratory study is the first study in a clinical program where the overall objective
is to develop a novel pharmaceutical therapy comprising local administration of GM-CSF for
the treatment of periodontitis. The project hypothesis is based on GM-CSF's antibacterial and
putative bone regeneration properties. Periodontitis is the major cause of tooth loss in
people over 35 years of age. An effective pharmacological treatment is today lacking and the
actual therapy would represent a new treatment option for the large patient group suffering
from the disease.