Overview A Single Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of MYK-491 Status: Completed Trial end date: 2017-11-28 Target enrollment: Participant gender: Summary Up to 72 healthy volunteers will be given a single dose of MYK-491 or placebo and be monitored for safety and tolerability over a 7 day period. Phase: Phase 1 Details Lead Sponsor: MyoKardia, Inc.