A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemo

• Status: Not yet recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the safety and effectiveness of immune cell therapy using autologous bone marrow-derived dendritic cells and immune checkpoint inhibitors in patients with metastatic pancreatic cancer who have failed at least one standard anticancer treatment.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Soonchunhyang University Hospital

Criteria

Inclusion Criteria:

• Patients histologically confirmed to have pancreatic cancer and diagnosed as recurrent or metastatic

• Patients whose disease was confirmed to have progressed according to RECIST v1.1 after 1st or more standard anticancer treatments

• Patients satisfying systemic performance status ECOG 0-2

• Patients who have not undergone surgery, radiation therapy, or immunotherapy within 4 weeks and have recovered from side effects (However, tissue collection procedures that do not affect the test subject's condition are permitted at the discretion of the researcher.)

• Patients who voluntarily agreed in writing to participate in this clinical study

Exclusion Criteria:

• Patients with malignant tumors other than non-melanoma skin cancer in the past 3 years

• Patients who have previously received anti-tumor immunotherapy (anti-PD1, anti-PDL-1, or CTLA4 inhibitor, etc.) or participated in clinical studies related to immunotherapy or cell therapy

• Patients with active autoimmune disease requiring systemic immunosuppressive treatment

• Patients with a history of organ or hematopoietic stem cell transplantation

• Patients with acute or chronic infection requiring systemic treatment

• Other cases where the test manager determines that it is not suitable for clinical research