Overview

A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.

Status:
Completed

Trial end date:
2010-02-26

Target enrollment:

Participant gender:

Summary

The present study will investigate in humans the enzyme inhibition effects of SB-649868 on CYP3A4, using Simvastatin and Atorvastatin as CYP3A4 probe substrates, administered as single doses: alone, and on two different occasions after repeat doses of SB-649868, at the same time as SB-649868 and 2h before SB-649868.

Phase:

Phase 1

Details

Lead Sponsor:

GlaxoSmithKline

Treatments:

Atorvastatin
Atorvastatin Calcium
Simvastatin