A Study Comparing CoQ10 Levels While Taking 3 Different Statins

• Status: Completed
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if Pitavastatin lowers CoQ10 less than Atorvastatin or Rosuvastatin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kansas; University of Kansas Medical Center
• Collaborators: Eli Lilly and Company; Kowa Pharmaceuticals America, Inc.
• Treatments: Atorvastatin; Atorvastatin Calcium; Pitavastatin; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• LDL-C levels of 100-200mg/dl; triglycerides
• Willing to discontinue use of all lipid-altering doses fo medication or supplements for the duration of the study

Exclusion Criteria:

• LDL-C <100mg/dl or >200mg/dl, Triglycerides >200mg/dl

• History of diabetes mellitus or documented fasting blood glucose >125mg/dl or HbA1c >6.4%

• History of coronary artery disease

• history of chronic renal or hepatic disease

• known sensitivity of intolerance to a statin

• persistent elevated liver enzymes or CPK (>3 x upper normal limit)

• currently taking CoQ10 supplements and unable discontinue for duration of study