A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis
Status:
Unknown status
Trial end date:
2017-07-01
Target enrollment:
Participant gender:
Summary
Cystic fibrosis (CF) is an inherited disorder which results in increased thickness of
secretions, especially in the lungs. By adulthood, the majority of patients with CF will have
a bacteria living in their lungs, called Pseudomonas aeruginosa which can cause lung
infections. This usually results in worsening respiratory symptoms and often an acute
deterioration in their lung function. They are usually treated with antibiotics that target
the Pseudomonas aeruginosa. These antibiotics are typically given as short intravenous
infusions several times a day. This study aims to compare the standard method of giving these
antibiotics with a different strategy of giving these antibiotics to see if this can improve
the outcomes of treatment of these infections and reduce the amount of Pseudomonas aeruginosa
in the lungs of these patients. This strategy consists of giving the same antibiotics
continuously, to ensure there is always enough antibiotic in the bloodstream and the lung to
be able to kill the bacteria.